Study: CBD Effective As Adjunctive Therapy For Schizophrenia

UNITED KINGDOM: The daily administration of CBD (cannabidiol) as an adjunctive therapy mitigates psychotic symptoms in patients with schizophrenia, according to clinical trial data published online ahead of print in The American Journal of Psychiatry.

British researchers assessed the adjunctive use of CBD compared to placebo over a six-week period in a randomized trial of 88 schizophrenic patients. Participants ingested 1000mg of plant-derived CBD per day in addition to their conventional medications.

Subjects in the CBD treatment group “had lower levels of positive psychotic symptoms and were more likely to have been rated as improved and as not severely unwell by the treating clinician” at the conclusion of the trial. CBD administration was also associated with “improvements in cognitive performance and in the level of overall functioning,” although these changes did not reach statistical significance.

“These findings suggest that CBD has beneficial effects in patients with schizophrenia,” authors concluded. “As CBD’s effects do not appear to depend on dopamine receptor antagonism, this agent may represent a new class of treatment for the disorder.”

Results of a prior clinical trial published in the journal Translational Psychiatry determined that CBD is superior to amisulpride, a potent anti-psychotic agent, in mitigating psychotic symptoms in schizophrenic patients.


For more information, contact Paul Armentano, NORML Deputy Director, at: paul@norml.org. Full text of the study, “Cannabidiol (CBD) as an adjunctive therapy in schizophrenia: A multicenter randomized controlled trial,” appears in The American Journal of Psychiatry.

You Don’t Have to Think Marijuana is Safe to Support Legalization

Project SAM’s Kevin Sabet and other prohibition advocates have seized on a new Wall Street Journal op-ed rehashing claims that marijuana use may be correlated with schizophrenia:Why isn’t this getting more play? Doc at Yale School of Medicine: Pot-Smoking & the Schizophrenia Connection  via @WSJ — Kevin Sabet (@KevinSabet) July 2, 2013

Washington Post blogger Jennifer Rubin, in a piece titled, “A Really Good Reason Not to Legalize Pot,” claims that “the move toward legalization of marijuana is premised on the assumption that it is ‘safe.’”

The argument that marijuana should be legalized because it is safe or safer than other substances like alcohol is an argument that some reformers often make, but it’s not an argument you’ll ever see me making, and it’s certainly not the only reason people in our movement want to end prohibition.

In my view, getting sucked into a debate over whether marijuana is good or bad is an unhelpful distraction from the core issues we need people to understand about prohibition.