Cannabinoids In Cannabis Help Treat Alzheimer’s Disease

In honor of World Alzheimer’s Month, we’ve asked educator/author Curt Robbins to provide an overview of how the cannabinoids in cannabis can be helpful in treating this mental illness.

By Curt Robbins

Discovered in 1906 by Dr. Alois (Aloysius) Alzheimer, a German psychiatrist and neuropathologist, Alzheimer’s disease is the sixth leading cause of death in the United States. Alzheimer stumbled upon the ailment when performing an autopsy on the brain of a woman who died of a then-unknown mental illness.

Surprisingly, Alzheimer’s disease begins damaging the brain up to a decade prior to the onset of any form of short-term memory loss—the stereotypical first discernible symptom of the disease that leads to a positive diagnosis.

The cannabinoids in cannabis help treat Alzheimer’s disease via a mechanism involving the removal of the excess plaques and tau tangles from the brain. Research indicates that some cannabinoids may transport these damaging plaques through the blood-brain barrier and out of the brain. Consumption of cannabinoids to remove plaque from the brain may result in improvement, but significant progress is strongly dependent on the progress of the disease with respect to how large a portion of the brain has suffered damage.

Formal research, anecdotal evidence, and personal testimonials have revealed that treatment with cannabinoids may slow or even halt the progression of Alzheimer’s disease. In some cases, memory function may be partially or mostly restored.

Read the entire article here:

Copyright © 2020 by Curt Robbins. All Rights Reserved.

Why Athletes Should Consider Taking CBD

It’s no secret that the life of an athlete can be rough. Hour after hour of cardio, lifting weights and refining your skill set is bound to be accompanied by soreness and other ailments that, if ignored, could lead to greater risk of injury. Of course, if you’re serious about your athletic goals, you’ve likely steeled yourself to the inevitability of injuries. “Pain is just weakness leaving the body” is a phrase that you’ve almost definitely heard at least once in your life, and while the sentiment is positive, it supports a flawed mindset.

As it stands, there are several ways in which you can address pre and post workout ailments, some being more natural than others. You could always try stretching properly and allowing your body adequate time to recover from the work it put in, but this is easier said than done. You won’t always get the chance to stretch/rest, and even if you do, you’ll really only be able to mitigate a small portion of the soreness and pain that you feel. Certain products and medications are being hailed for their anti-inflammatory effects, but the negatives that come with them far outweigh the relief that they may or may not bring.

As professional athletes are discovering, there are more natural means of achieving relief that avoid the dangers of addictive prescriptions and other potentially harmful products. CBD is a potential answer to many of the aches and pains that you suffer from in your athletic ventures. In multiple studies, the compound has been found to possess anti-inflammatory properties, preventing you from encountering much of the soreness that you would usually encounter.

CBD, or cannabidiol, enters your body and is absorbed into your bloodstream, where it seeks out the receptors that make up your endocannabinoid system. This system runs throughout your body and is a key component in ensuring that your body remains in homeostasis — a state that is disrupted by pain and inflammation, among other things. It produces its own form of cannabinoid, which is sent and received by different receptors within the system. When CBD is introduced to this system, it can act as an endocannabinoid, both boosting the system’s activity and preventing the release of certain neurotransmitters that would result in feelings of pain and discomfort.

It only makes sense, then, that CBD would be embraced by the world of athletics with open arms. Athletes could benefit from adding CBD products to their daily workouts, and they could even use these products as part of their pre and postgame routines as well. It would provide them with a means of recovering from especially intense workouts and games, potentially preventing them from waking up and having to will their bodies out of bed the following morning.

CBD products such as CBD balms and hemp creams are the perfect gym buddies, fitting into any bag and offering availability at a moment’s notice. Unlike the creams and balms that can normally be found in gym bags, these also boast servings of high-quality CBD hemp extract, and if you’re buying from reputable sources, such as the lab-tested products by CBDfx, you’re sure to get a product that walks the walk.

While the number of active athletes backing CBD might seem small, it’s mainly because of the rules currently prohibiting the compound. For years, CBD has been lumped in with other compounds found in cannabis plants that possess psychoactive effects, and therefore it’s been kept away from professional athletes. However, now that it’s widely understood that CBD doesn’t possess any psychoactive or intoxicating effects, sports leagues are warming up to the compound.

Meanwhile, multiple prominent ex-professional athletes are championing the cause for CBD in athletics, including those with backgrounds in everything from baseball to bicycling. MLB and NBA hall of famers such as Goose Gossage and Rick Barry are actively campaigning for the acceptance of CBD as an alternative to the more controversial medications that athletes are currently being subjected to.

Many ex-pro sports advocates are also pointing to CBD’s anxiolytic (anti-anxiety) effects as a reason for the compound to be permitted for athletes. Social anxiety is just as prevalent amongst athletic superstars as it is for the rest of the world, and ex-NBA champion Paul Pierce is even on record stating that he used CBD for the express purpose of curbing his feelings of anxiety and depression.

With a million reasons to embrace CBD and little to no reason not to, it seems obvious that the compound should — and will — thrive once made more available to athletes and the world of sports in general. Its anxiolytic and anti-inflammatory attributes are only the tip of the iceberg, and its other facets will prove just as crucial to your own athletic aspirations. It’s only a matter of time before the floodgates open and CBD gains the limelight that it so rightfully deserves.

Sources:

  1. Vučković, Sonja, et al. “Cannabinoids and Pain: New Insights From Old Molecules.” Frontiers, Frontiers, 15 Oct. 2018, www.frontiersin.org/articles/10.3389/fphar.2018.01259/full.
  2. Small, Jonathan. “Why Paul Pierce Jumped On The CBD Train.” GreenEntrepreneur, 15 Nov. 2019, www.greenentrepreneur.com/article/340942.
  3. Iffland K, Grotenhermen F (2017) An update on safety and side effects of cannabidiol: a review of clinical data and relevant animal studies, Cannabis and Cannabinoid Research 2:1, 139–154, DOI: 10.1089/can.2016.0034.

Case Reports: Cannabinoids Improve Speech In Patients With Tourette Syndrome

GERMANY: The daily administration of cannabinoids is associated with improved speech fluency in patients with Tourette Syndrome (TS), according to a pair of case reports published in The International Journal of Molecular Sciences.

A pair of researchers from the Hannover Medical School in Germany assessed the impact of daily cannabinoid treatment in two TS patients with treatment-resistant vocal blocking tics. One patient underwent therapy utilizing THC-dominant whole-plant cannabis. The other utilized dronabinol (oral THC).

In both cases, authors reported that treatment resulted in “significant improvement not only of simple and complex motor and vocal tics, but also in the overall symptomology including comorbid conditions and most importantly significantly improved patients’ quality of life including their social contacts and performance at school without side effects.”

They concluded, “[C]annabis-based medicine appears to be effective in treatment-resistant TS patients with vocal blocking tics.”

Prior studies and case reports have similarly demonstrated that the administration of either inhaled cannabis or oral synthetic THC is associated with substantial improvements in TS-related symptoms.

For more information, contact Paul Armentano, NORML Deputy Director, at: paul@norml.org. Full text of the study, “Speechlessness in Gille de la Tourette Syndrome: Cannabis-based medicines improve severe vocal blocking tics in two patients,” appears in The International Journal of Molecular Sciences.

Review Identifies 140 Controlled Clinical Trials Related to Cannabis

GERMANY: Scientists have conducted over 140 controlled clinical trials since 1975 assessing the safety and efficacy of either whole-plant cannabis or specific cannabinoids, according to a literature review published in the journal Critical Reviews in Plant Sciences.

A pair of German researchers identified 140 clinical trials involving an estimated 8,000 participants. Of these, the largest body of literature focuses on the use of cannabis or cannabinoids for the treatment of chronic or neuropathic pain. Authors identified 35 controlled studies, involving 2,046 subjects, assessing the use of marijuana or cannabinoids in pain management. In January, the National Academy of Sciences acknowledged that “conclusive or substantial evidence” exists for cannabis’ efficacy in patients suffering from chronic pain.

Cannabinoids have also been well studied as anti-emetic agents and as appetite stimulants. Researchers identified 43 trials evaluating marijuana or its components for these purposes, involving a total of 2,498 patients. They identified an additional 14 trials examining the role of cannabis or cannabis-derived extracts for the treatment of multiple sclerosis.

Researchers also identified several additional trials evaluating the use of cannabis or cannabinoids for a number of other diseases, including Crohn’s disease, Tourette’s syndrome, Parkinson’s disease, glaucoma, and epilepsy.

A 2014 study published in the Journal of the American Medical Association reported that pharmaceutical drugs typically gain FDA approval on the basis of one or two pivotal clinical trials.

 

What Is CBD? The Everyday Guide To Cannabidiol

COLORADO: CannaInsider.com has published a comprehensive guide to CBD, the miracle cannabinoid endorsed and made popular in 2013 by a documentary produced by mainstream media health expert, Dr. Sanjay Gupta of CNN.

Cannabidiol (CBD) is one of over 80 chemical compounds found in the cannabis plant called cannabinoids. Cannabinoids bind to receptors in the brain and body and are responsible for the effects of cannabis, like feeling high, relaxed, or euphoric. The most popular cannabinoid, THC, is widely known as the compound that produces a high feeling.

CBD, which is rapidly gaining popularity, is known for its immense healing properties that are just being discovered as scientific research into the cannabis plant expands. Gupta’s documentary profiled five-year-old Charlotte Figi, who reduced her 300 seizures a week to just one a day with CBD treatment. CannaInsider’s Guide details what the scientific community knows about CBD and explains how the legal marijuana industry is responding. Learn more about CBD with CannaInsider’s Guide: http://www.cannainsider.com/reviews/what-is-cbd/.

“CBD is quickly expanding beyond the medical marijuana community and into totally new demographics (senior citizens and athletes, to name just two). This rapid growth is certain to continue as more and more individuals discover how CBD can play a positive role in their own healthcare outcomes,” said Patrick O’Malley, President of Good Life Colorado — the world’s only marijuana product incubator.

Dr. Noel Palmer, Ph.D., The Chief Scientist at Mary’s Medicinals, an infused products company in Denver is equally enthusiastic the excitement around CBD, “CBD has amazing therapeutic efficacy for a large variety of conditions, but it doesn’t get you stoned. For those who want a plant-derived medicine, CBD is an great option with very few negative side effects.”

In the CNN documentary, Figi treated her severe Dravet Syndrome with a CBD oil produced by the popular Colorado-based brand, Realm of Caring, made from a strain of high CBD cannabis plants. However, CBD can also be found in the hemp plant. Hemp products are distributed nationally and are regulated by the Department of Agriculture. You can purchase CBD online and have it shipped to your home within the United States.

So, how do you distinguish between what’s quality and what’s not? CannaInsider.com also reviews CBD oil and products with in-depth analysis and pictures at: CO.

As America’s fastest growing industry, the legal cannabis industry is navigating unchartered territory by producing and selling products made from a versatile plant that has been in the shadows for the last 80 years. CannaInsider.com has published a glossary of terms related to the marijuana plant and industry to educate those interested in learning more. Explore this dictionary at: http://www.cannainsider.com/reviews/glossary/.

The Arthritis Society Canada Funds More Medical Cannabis Research Amid Legalization Speculation

New clinical trial will study use of oral cannabinoids for fibromyalgia pain

CANADA: The Arthritis Society has announced the winner of its latest research grant for the study of medical cannabis and arthritis. McGill University’s Dr. Mark Ware, who has garnered a worldwide reputation as a leader in pain research, will lead a trial examining the use of oral cannabinoids for fibromyalgia — a disease that inflicts chronic pain on some 520,000 Canadians, most of them women1.

The study was selected from among several proposals submitted by Canadian researchers to receive the three-year grant, following an extensive peer review process by an impartial volunteer panel of cross-disciplinary medical and scientific experts as well as arthritis health consumers.

This is the second medical cannabis research project The Arthritis Society has funded in the past 18 months: in 2015, Dr. Jason McDougall was awarded a similar three-year grant to study the impact of medical cannabis on arthritis pain and disease management.

“These investments are about leading by example,” says Arthritis Society president and CEO Janet Yale. “Patients and physicians both need to be able to make informed decisions about whether cannabis has a place in the individual’s treatment plan. With these commitments, The Arthritis Society is doing its part to help fill some of the critical knowledge gaps around medical cannabis, but we can’t do it alone. There’s no reason for the government to wait until new legislation is in place to start addressing the need for research identified by their own task force. That’s why we continue to call on the federal government to make a firm commitment in the 2017 budget to fund $25 million in medical cannabis research over the next five years.”

Impact of fibromyalgia

Fibromyalgia is a chronic disease that affects the central nervous system, delivering widespread pain throughout the body. Pain can vary in location and intensity on a daily or even hourly basis, and can come with a host of other symptoms such as fatigue, sleep difficulties, lack of concentration and memory, mood swings, gastrointestinal problems and heightened sensitivity to touch and pressure.

Many fibromyalgia patients have reported that cannabis has positive effects on pain and symptom management, but this has not yet been confirmed in large-scale clinical trials. This study will be used to help educate patients and health professionals regarding the possible risks and benefits of oral cannabis in fibromyalgia therapy.

“This disease has a tremendous impact on a person’s life,” Dr. Ware explains, “but to date we haven’t really had any good treatment options to offer. Opioids and NSAIDs for pain management are often ineffective for fibromyalgia pain, or can have serious negative side effects — especially when used for prolonged periods. We hope to identify whether oral cannabinoids can offer the person with fibromyalgia hope for relief from their symptoms, and help restore their quality of life. We are grateful for the support of The Arthritis Society for this important project.”

New regulatory framework

The announcement comes just days after the report of the federal task force on legalization and regulation of marijuana was made public. That report echoes the priorities expressed by The Arthritis Society and other patient advocacy groups about ensuring that the new regulatory regime addresses patient concerns, with a priority on access, affordability and the vital need for more research. Earlier this fall, The Arthritis Society led a joint submission to the task force by patient advocates, and followed it up by co-facilitating a meeting where task force members heard directly from patients who use medical cannabis. The government is expected to issue new legislation as early as Spring 2017.

Two thirds of people who use cannabis for medical purposes are doing so to help cope with the pain, fatigue and other symptoms of arthritis.

“In the rush to legalize cannabis for recreational use, we need to be careful that the needs of people who rely on cannabis for medical purposes aren’t forgotten,” says Yale. “We will be watching closely to ensure that the new regulations put patients’ needs first.”

Pot-Based Dog Treats: Owners Claim They Cure Pets’ Ailments

CALIFORNIA:  Some pet owners are claiming that hemp-based treats cure many of their pets’ ailments. The treats are infused with cannabinoids or CBDs but don’t have THC, so the animal doesn’t get high. One of the hemp-based treat brands called Treatibles has been used by some owners for anxiety or stress in their dogs. Andrew Mizia stated that his dog Fred can be stressed when around other dogs, and he stated the following regarding the result when he gives the canine the treat, according to ABC Channel 7.

These treats are flying off the shelves, because many pet owners have claimed that the treats can cure illnesses ranging from arthritis to epileptic seizures. The manager of one store that carries a large variety of calming treats claims that the Treatibles are more effective in treating anxious animals because of the cannabinoids. The manager of the Holistic Hound, a store in Oakland, Dianne Krenzer, stated the following. “I’ve never seen a product that has had such broad popularity and interest. Humans and animals have an endocannabinoid system and we have receptors throughout our bodies. So if anxiety is an issue, the CBD works on the stress receptors.”

The treats are intended primarily for dogs, but have even been used with other domestic and farm animals. They contain 40mg of CBD per treat. The manufacturer recommends one treat per 20 pounds. And some owners even rave about the success they’ve had with the treats in saving their animal’s lives. An owner named Wendy who has a 15-year-old lab mix named Kali decided to try the treats out of desperation, as she had scheduled an appointment to euthanize the dog in order to alleviate its chronic pain. Wendy stated the following, according to the Examiner.

 

Dr. Ethan Russo On Clinical Endocannabinoid Deficiency

WASHINGTON:  This week I made the trek to Vashon Island to see a talk on Clinical Endocannabinoid Deficiency by Dr. Ethan Russo at the monthly VIMEA meetup.

Speaking to a full room of cannabis patients, growers, processors, and enthusiasts, Dr. Russo zoned in on chronic medical conditions that demonstrate endocannabinoid deficiency.

One of the biggest things that I took away was his point that the fact that the brain and the gut are very connected. You can’t have a healthy brain without a healthy gut and vice versa. I also appreciated that he mentioned other natural ways to boost your endocannabinoid system: proper sleep, cardiovascular exercise, and consuming an anti-inflammatory diet.

An Evening With Dr. Ethan Russo: The Terpene AfterBuzz

By TwicebakedinWA

WASHINGTON:  On Tuesday I took a little adventure on a ferry over to Vashon Island for the monthly Vashon Island Marijuana Industry Alliance (VIMEA) Meetup. It was the second one that I have been to and it did not disappoint.

The first time I went to one of their Meetups was last month and it was there that I initially met Dr. Ethan Russo and learned that he would be speaking this month. I immediately put that event into my schedule.

In case you don’t know, Dr. Ethan Russo is a world renowned cannabis researcher, neurologist, and author. He spent an hour talking to a very packed house about terpenes and the entourage effect. I was sitting on the floor in the very front with my notebook and pen taking down the points that didn’t go over my head.

See the Video here:

[youtube http://www.youtube.com/watch?v=-W1WLe2ehyc&w=560&h=315]

Florida Lawmaker Agrees To Work To Legalize Medical Marijuana High In Cannabidiol

FLORIDA:  Hope came Thursday for families whose children suffer from epileptic seizures, as the chairman of a key legislative committee agreed to file a bill to legalize the medical use of marijuana that has a high content of the chemical compound cannabidiol.

“Our work is only beginning,” said Rep. Matt Gaetz, R-Shalimar, after the House Criminal Justice Subcommittee heard testimony for nearly two hours from parents of children from Miami, Weston, Tampa, Pensacola and even Colorado. [Read more…]