UNITED KINGDOM: Cannabis smoke exposure, even long-term, is not positively associated with chronic obstructive pulmonary disease (COPD), lung cancer, or irreversible airway damage, according to a literature review published in the journal Breathe.
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CALIFORNIA: Cannabis smoke exposure is not particularly detrimental to lung health and is not associated with the onset of lung cancer, emphysema, or COPD, according to data published in the journal Chest.
Donald Tashkin of UCLA’s David Geffen School of Medicine reviewed dozens of studies assessing cannabis smoke exposure and lung health, involving thousands of subjects.
He reports: “Although regular smoking of marijuana is associated with an increased risk of symptoms of chronic bronchitis and evidence of inflammation and injury involving the larger airways, lung function findings, although mixed, do not provide compelling evidence that habitual marijuana smoking in the manner and amount that it is generally smoked increases the risk of COPD, at least at the population level. Despite the presence of carcinogens in marijuana smoke in concentrations comparable with those that are found in tobacco smoke, the weight of evidence from well-designed epidemiologic studies does not support the concept that habitual marijuana use in the manner and quantity in which it is customarily smoked, when adjusted for tobacco, is a significant risk factor for the development of lung cancer.”
Studies also fail to show a relationship between cannabis smoking and decrements in lung function, and “argue against an association of marijuana with clinically significant emphysema.”
Tashkin’s findings are similar to those of past reviews finding that cannabis smoke exposure fails to possess the same sort of significant adverse pulmonary effects as does tobacco.
For more information, contact Paul Armentano, NORML Deputy Director, at: email@example.com. Full text of the study, “Marijuana and lung disease,” appears in Chest. NORML’s fact-sheet, “Cannabis exposure and lung health,” appears online.
COLORADO: Long-term exposure to cannabis smoke is not associated with significant adverse effects on pulmonary function, according to clinical data published in the journal Chronic Obstructive Pulmonary Diseases.
A team of investigators led by researchers at the Colorado School of Public Health assessed the relationship between marijuana use and respiratory function in a cohort of 2,300 subjects ages 40 to 80, many of whom also smoked tobacco.
Authors reported, “Neither current nor former marijuana use was associated with increased risk of cough, wheeze, or chronic bronchitis when compared to never marijuana users. … Current and former marijuana smokers had significantly higher FEV1 (forced expiratory volume) … when compared to never users. … Both current and former marijuana use was associated with significantly less quantitative emphysema … when compared to never users, even after adjusting for age, … current tobacco smoking pack years, and BMI. … In agreement with other published studies, we also did not find that marijuana use was associated with more obstructive lung disease.”
Researchers also reported that the long-term combined use of tobacco and cannabis was not associated with any additive adverse effects on the lungs. They concluded, “Among older adults with a history of tobacco use, marijuana use does not appear to increase risk for adverse lung function. … There may be no to little increased risk of marijuana use for a further increase in respiratory symptoms or adverse effects … among those with a history of concomitant tobacco use.”
Prior longitudinal studies assessing the effects of long-term cannabis smoke exposure on lung function have similarly reported that subjects’ marijuana use history is not positively associated with increased incidences of chronic obstructive pulmonary disease (COPD), lung cancer, or with other significant detrimental effects on pulmonary function.
For more information, contact Paul Armentano, NORML Deputy Director, at: firstname.lastname@example.org. Full text of the study, “Marijuana use associations with pulmonary symptoms and function in tobacco smokers enrolled in the subpopulations and intermediate outcome measures in COPD Study (SPIROMICS),” appears in Chronic Obstructive Pulmonary Diseases.
ISRAEL: iCAN Israel-Cannabis and Aura Medical have joined forces to bring FDA approved nebulizers to the burgeoning medical cannabis market.
The Aura’s Portable Nebulizer is widely acclaimed and recommended by the nation’s top Pulmonologists and Respiratory Therapists for use in treating asthma and COPD and now will be used by millions more worldwide. The device will be marketed under the brand name “Nebican.”
Utilizing specially developed controlled dosages, the Nebican portable nebulizer is a perfect delivery system for medical cannabis. Nebican is the answer to medical practitioners and patients worldwide as demand turns towards medical cannabis to alleviate numerous ailments.
Designed with patented Vibrating Mesh Technology (VMT), Nebican is an innovative form of atomization that emits extremely thin and fog like vapor. Like air, the mist released from the inhaler can easily penetrate deep into the lungs. Pocket sized, it is portable, discreet, convenient and easy to use.
Company Announces €20 Million Investment to Build EU Campus and Begin Operations this Year
PORTUGAL: Tilray has announced plans today to invest up to €20 million in a European Union Campus after receiving licenses from the Government of Portugal to import cannabis genetics and to cultivate cannabis for medical purposes.
“Tilray’s EU Campus is another strategic milestone as we aim to build the world’s most trusted and admired medical cannabis brand,” said Brendan Kennedy, Chief Executive Officer of Tilray. “For the past two years we’ve been working hard to find the right location for cultivation, processing, and research facilities to serve rapidly growing demand for high-quality medical cannabis products in Europe. Portugal has the ideal climate to cultivate cannabis, a highly-skilled health care workforce, and a vibrant research community. It’s more environmentally-friendly and cost-effective to supply European patients from Portugal than from northern climates.”
State-of-the-Art EU Campus Will Begin Operations This Year
To establish the EU Campus, Tilray will invest up to €20 million through its affiliate, Tilray Portugal Unipessoal Lda., in multiple facilities located in and around the BIOCANT Research Park in Cantanhede, Portugal. The EU Campus will include indoor, outdoor, and greenhouse cultivation sites, as well as facilities to process, package, and distribute medical cannabis and cannabinoid-derived medical products. As a part of the BIOCANT biotechnology and life sciences research park, the EU Campus will serve as a hub supporting Tilray’s clinical research and product development efforts across Europe.
Tilray is currently leasing laboratory and indoor cultivation space within BIOCANT. This month, Tilray will begin construction on a greenhouse and a processing facility on property purchased by the company. Phase one of the project, which is expected to be complete by spring of 2018, includes an indoor laboratory and genetics bank, outdoor cultivation sites, a 10,000 m2 greenhouse, and a 1,500 m2 processing facility. Subsequent phases, which are expected to be completed by 2020, will add 15,000 m2 of greenhouse cultivation space and another 1,500 m2 for processing. Over the next three years, the project is expected to create 100 direct jobs, including highly-skilled positions.
EU Campus Accelerates Tilray’s Global Expansion Strategy
In response to considerable unmet need for high-quality medical cannabis, Tilray is investing aggressively to expand its operations around the world. In addition to Tilray Portugal Unipessoal Lda., Tilray has wholly-owned subsidiaries in Germany (Tilray Deutschland GmbH), Canada (Tilray Canada Ltd.), and Australia and New Zealand (Tilray Australia and New Zealand Pty. Ltd.).
Tilray has a proven track record as a global pioneer in the medical cannabis industry:
- In 2014, Tilray was one of the first companies to be federally-licensed to cultivate, process and distribute medical cannabis in Canada.
- In December 2016, Tilray became the first medical cannabis licensed producer in North America to be GMP-certified in accordance with the European Medicines Agency’s (EMA) Good Manufacturing Practice (GMP) standards. GMP certification is the most rigorous standard that manufacturers of medical products must meet in their production processes. In countries new to medical cannabis, GMP certification provides regulators and health care providers with certainty that Tilray products are a safe and smart choice.
- In 2016 and 2017, Tilray launched clinical research partnerships with world-leading hospitals and universities to study the safety and efficacy of medical cannabis for a diverse range of conditions, including post-traumatic stress disorder (PTSD), chronic obstructive pulmonary disorder (COPD), pediatric epilepsy, and chemotherapy-induced nausea and vomiting (CINV).
- Throughout the last year, Tilray became the first company to legally export medical cannabis products from North America to the European Union, Australia, New Zealand, and South America. Tilray products are currently available in six countries spanning four continents.
By the end of 2017, Tilray expects to export medical cannabis products to five more countries. The company also anticipates announcing federal licenses from additional countries, as well as research partnerships in Portugal, Germany, and other countries around the world.
Tilray Portugal Timeline
Tilray executives first visited Portugal in 2015. After conducting extensive due diligence, consultation with stakeholders, and a country-wide property search, Tilray reached a Memorandum of Understanding with the Government of Portugal in October 2016. Tilray Portugal Unipessoal Lda. was incorporated in March 2017. The company purchased property in Cantanhede in July 2017.
CANADA: Tilray, a global leader in medical cannabis research and production, today announced a partnership with the Research Institute of the McGill University Health Centre (RI-MUHC) in Montreal, one of the world’s premier public academic and research institutions, to study the effects of vaporized cannabis on symptoms associated with chronic obstructive pulmonary disease (COPD).
The Phase II trial will study the efficacy of medical cannabis on breathlessness, and exercise tolerance in symptomatic patients with advanced COPD. Patients with COPD suffer from chronic, progressive lung diseases that obstruct airflow and can cause irreversible lung damage without intervention. The pathophysiological hallmarks of COPD include expiratory flow limitation; pulmonary gas trapping and lung hyperinflation; gas exchange abnormalities; and mucus hypersecretion. These pathophysiological hallmarks are linked to breathlessness, loss of autonomy, and a diminished quality of life. Patients with COPD also often avoid exercise, leading to psychological co-morbidities, such as anxiety and depression, and a decrease in overall health.
COPD is a leading cause of morbidity, mortality, and socioeconomic burden in Canada and around the world. Estimates suggest that approximately 17% of Canadian adults over the age of 40 suffer from COPD. Symptom management is critical for COPD patients to ensure that their condition remains stable and their quality of life is maintained. Nonetheless, an estimated 45-90% of adults with advanced COPD suffer from chronic and disabling physical activity-related breathlessness, despite optimal treatment of their underlying lung disease with existing and approved pharmacotherapies (e.g., bronchodilators, corticosteroids). There is a critical need to develop more effective therapies for COPD.
The research team led by Drs. Dennis Jensen and Jean Bourbeau will conduct the trial at the McConnell Centre for Innovative Medicine of the RI-MUHC. “Adjunct therapies targeted to relieve breathlessness and improved exercise tolerance are needed to enhance health outcomes for adults with advanced COPD, and medical cannabis is a potential therapy of interest,” said Dr. Jensen. Patient recruitment for the trial, which will involve 20 participants, is already underway, and the trial is expected to conclude later this year.
“Tilray is proud to support this important research,” said Dr. Catherine Jacobson, Director of Clinical Research at Tilray. “If we find that vaporized cannabis is safe, well-tolerated, and effective, we can conduct further research to help people with COPD and other medical conditions manage their symptoms effectively.”
Tilray is committed to advancing the science and safety of medical cannabis products by supporting clinical research. The COPD trial is one of several research efforts underway. In Canada, Tilray supports additional clinical trials focused on pediatric epilepsy at SickKids Hospital and post-traumatic stress disorder at the University of British Columbia. In Australia, Tilray has partnered with the University of Sydney and New South Wales Government to study medical cannabis as a treatment for symptoms of chemotherapy-induced nausea and vomiting.
Tilray is a global leader in medical cannabis research and production dedicated to advancing the science, efficacy and safety of cannabinoid medicine for patients with a diverse range of conditions. The company operates one of the largest and most sophisticated federally licensed medical cannabis cultivation facilities in the world, offering a range of products to patients, pharmacies and researchers in Canada, Australia, the European Union and the Americas.
CALIFORNIA: The pulmonary consequences of regularly smoking marijuana are far less than for tobacco, according a review of the published evidence conducted by Dr. Donald P. Tashkin, emeritus professor of medicine and medical director of the pulmonary function laboratory at the University of California, Los Angeles. [Read more…]