Search Results for: CBD-based products

Basketball Legend Al Harrington Premiers CBD-Based Wellness Products

CALIFORNIA: Retired NBA great Al Harrington, who discovered the benefits of CBDs (Cannabinoids) at the end of his playing career, has premiered a new line of wellness products based on hemp, the non-psychoactive elements found in the plant. As an upscale consumer brand, Harrington Wellness will feature products that will foster healthy living and all the benefits that come from it.

Harrington introduced the new brand at a star-studded dinner last night in Beverly Hills at the start of the NBA’s 2018 All-Star Weekend that is taking place in Los Angeles.

“After more surgeries than I care to admit, my knee was shot, and I was in pain all the time,” said Harrington, CEO of Harrington Wellness and founder of The Harrington Group. “If I had the benefit of CBDs, like our Harrington Wellness Cream when I was playing, there’s no doubt I could have played two or three more seasons in the NBA.”

It was Harrington’s fall 2017 “Uninterrupted” online interview with retired NBA Commissioner David Stern, which has generated over 122,000 views on YouTube and more than one million total across various websites, that led to the creation of Harrington Wellness.

“David and I were talking about the benefits of CBDs and how NBA players could benefit from them,” added the former New York Knicks and Denver Nuggets forward. “That interview led to lots of interest and an outpouring of support, so I created Harrington Wellness to fill the unserved niche of upmarket, professional and premium CBD products that are legal anywhere in the country.”

Harrington initially discovered the recuperative power of Cannabis, and later CBDs, as a result of convincing his grandmother, Viola, to use extracts to help with her glaucoma. As a result, Harrington Wellness’ sister company, Viola Extracts, is named in her honor.

Nutritional High Announces Exclusive Partnership For Jimi Hendrix Products

DISTRICT OF COLUMBIA:  Nutritional High International Inc. (the “Company” or “Nutritional High”) (CSE:NHL)(OTCQB:SPLIF) is pleased to announce that the Company has entered into an exclusive licensing agreement (“Agreement”), under which the Company may manufacture and distribute various marijuana and hemp-based edible products using the song titles and bearing the likeness of iconic guitarist Jimi Hendrix.

Jimi Hendrix is one of the most legendary rock guitarists of all time and this partnership should create instant brand recognition for our edible marijuana products by Jimi’s fans across North America,” said David Posner, CEO of Nutritional High. “Entering into brand partnerships with the world’s foremost marijuana-related artists is a core component of our strategy, and we are honored to become part of Jimi’s legacy,” he added.

A variety of products under the “Edibles Experience” banner are in development including the “Purple Haze” line of THC-based products and the “Stone Free” line of CBD-based, non-psychoactive health products.

 

Cannabis and Hemp Extraction Explained: Ethanol vs. Supercritical

The hemp industry is projected to grow into a $16 billion industry by 2025, and the cannabis (legal marijuana) industry is expected to grow to a $66.3 billion industry during the same period. Keeping this trend in mind, it is now a good time as ever to invest in these burgeoning markets. And if you are a consumer of hemp or cannabis-based products, expect to choose from a wide variety of CBD based products ranging from oils, creams, and balms to foods, beverages, and tinctures.

So why is the industry booming? First off, the demand for CBD based products is on the rise. This is attributed to the fact that CBD has numerous health benefits, such as managing anxiety and depression, relieving chronic pain, treating acne, and alleviating cancer-related symptoms. As an organic option, it has gained considerable popularity among people who want to distance themselves from the side effects of pharmaceutical drugs.

Secondly, the recent wave of legalization of the hemp industry has generated an influx of new entrants in the market. Many countries, including the US and most countries in Europe, allow the manufacture, sale, and purchase of hemp-based CBD products with regulated amounts of tetrahydrocannabinol (THC). THC is one of the hundreds of cannabinoids found in the cannabis plant and it is responsible for giving the user a “high”. Therefore, with strict regulations on THC content, usually below 0.3%, CBD products are being made safe to consume.

As for cannabis-based CBD products, many analysts and professionals in the field claim that the legalization of cannabis is not a matter of “if” but a matter of “when”. While some countries, such as Australia, have only legalized medical cannabis, others, such as Canada, have made it completely legal. It is expected that the wave of global cannabis legalization is imminent.

Furthermore, changes in public perception regarding the legalization and consumption of CBD products have transformed the industry. With people favorably viewing both cannabis and hemp for their numerous medical benefits, the previously held stigma attached to cannabis plants is rapidly dissipating.

Since CBD-based products have garnered massive demand and attention, it is only logical to assume that consumers want the best products on the market. In this regard, it is exceptionally helpful for consumers to familiarize themselves with the different methods of cannabis and hemp extraction. Since the quality, purity, and potency of the final product directly depends on its extraction from the cannabis plant, it is helpful to recognize different extraction methods.

This article will explain the difference between the two most widely used cannabis and hemp extraction methods, namely ethanol extraction and carbon dioxide (CO2) supercritical extraction. So read on to find out the processes, advantages, and disadvantages of each method.

Ethanol Extraction of Cannabis and Hemp 

With rapid advancements in technology, companies have been able to build cannabis extraction machines that allow for safe, efficient, clean and environmentally friendly extraction of hemp and cannabis. These machines are specifically built to be sustainable and provide economies of scale for commercial production.

In this regard, one of the most innovative methods of extraction has been the development of the ethanol extraction system. While ethanol extraction has been used in the food and pharmaceutical extraction industry for decades, the latest ethanol extraction machines have successfully eliminated the need for post-processing methods such as winterization and filtration.

Ethanol

How Does Ethanol Extraction Work?

Since ethanol is a highly polar solvent, it can bind to virtually all the substances in the cannabis plant. This means that unwanted compounds, such as fats, lipids, waxes, and even chlorophyll can be extracted. Previously, attempts at extracting CBD from cannabis or hemp using room-temperature ethanol required post-processing techniques to separate the essential from the non-essential compounds.

However, engineering efforts have found a way around that. Nowadays, ethanol is supercooled and its polarity is manipulated so that it only extracts the desirable compounds from the cannabis plant or the biomass. The ethanol makes use of something called a negative pressure to “pull” out the cannabinoids and terpenes from the cannabis or hemp plant.

This process requires a Solvent Storage Tank for the supercooled ethanol, a Holding Tank for the cannabis or hemp plant, and an Extraction Vessel for the ethanol to pass through the plant to extract the useful chemical compounds. Highly efficient machines may contain other pieces of equipment, such as sock filters and pneumatic actuators to help filter out the plant material and maintain pressure differentials, respectively.

Advantages And Disadvantages Of Ethanol Extraction

Following are the advantages of ethanol extraction:

  • It helps achieve a 98.6% efficiency during extraction.
  • It is safe to use since it eliminates the need for heat or high pressure. Ethanol is also FDA approved as a food-grade solvent.
  • It does not require post-processing.
  • The end-product is of superior quality and high concentration.

Following are the disadvantages of ethanol extraction:

  • The equipment may require considerable investment costs.
  • Skilled people will be needed to operate the machinery.

Supercritical CO2 Extraction of Cannabis and Hemp 

Carbon Dioxide is another widely used method of cannabis and hemp extraction. Since CO2 is a gas, changes in temperature and pressure are needed to convert the CO2 into a solvent state to enable it to extract the needed cannabinoids. This state, referred to as supercritical, allows the CO2 to behave both like a gas and a liquid at once.

How Does CO2 Extraction Work?

The CO2 extraction method primarily uses three different equipment. The Compression Chamber helps the CO2 to go beyond its critical state, therefore converting it into supercritical CO2. This is passed through the cannabis or hemp plant in the Extraction Vessel to pull out the useful compounds. The desirable components of the extraction process are then collected in a Separator while the CO2 is condensed and prepared to be reused for the next extraction cycle.

The process, which uses high pressure, requires somewhere between 1500 psi to 2000 psi. This makes it demanding in terms of power requirements. Furthermore, CO2 is considered a weak solvent, which means that that extraction cycle must last a minimum of two hours and still have a yield below that which is achieved from ethanol extraction. This makes it rather difficult to scale out the production process using CO2 extraction method.

Advantages And Disadvantages Of CO2 Extraction

Following are the advantages of CO2 extraction:

  • It doesn’t contain any residuals post-extraction.
  • The equipment can be tuned and customized for a specific type of extraction, such as temperature-sensitive extraction.
  • It doesn’t pull out any large unwanted molecules such as chlorophyll.

Following are the disadvantages of CO2 extraction:

  • CO2 is a weak solvent compared to ethanol.
  • The equipment is very costly and needs high safety standards for setting up.
  • The usage of high pressure and temperature requires superior safety standards.
  • The machinery is advanced and requires technical expertise.
  • The machinery is prone to wear and tear due to high-pressure used in the process.

CBD-Infused Foods Becoming A New Health Trend

NEVADA: CBD-infused foods are gaining strong momentum in the market as consumers demand more healthy food options. CBD is considered a healthy alternative to pharmaceuticals that have horrible side effects, like opioids. It can be used as one component in holistic health treatments. As CBD-oil infused markets continue to gain traction, healthy food options are growing.

Traditionally, consumers think of CBD-oil infused edibles as cookies, gummy bears, or brownies. Now companies are producing healthy food products to meet the needs of those seeking healthy alternatives to traditional CBD-infused snacks. CBD is a non-intoxicating cannabis compound with several therapeutic properties. Infusing this compound into healthy foods is helping consumers fight anxiety, pain, over-eating, and insomnia.

Hemp Business Journal estimates the hemp industry will grow to $1.8 billion in sales by 2020, led by hemp food, body care, and CBD-based products. The enormous potential for expansion shows big revenue possibilities for investors and companies as operations and new products hit the market almost daily.

Elev8 Hemp Coffee Now Available On Amazon Prime

FLORIDA: In another example of the mainstreaming of hemp and cannabis products, Elev8 Brands, Inc., a holding company focused on the commercial development of hemp and CBD-based products including hemp coffee, tea, and E-juices, has announced that Elev8’s Hemp Coffee is now approved and available for customers with Amazon Prime accounts.

Elev8 Hemp Coffee is officially fulfilled by Amazon following Elev8 Hemp Tea from earlier this month. Fulfillment by Amazon will provide quicker and cheaper delivery times allowing for greater penetration in the online market.

Chief Executive Officer Ryan Medico commented, “We are excited to now have Elev8 Hemp Coffee available for Amazon Prime subscribers. With both coffee and tea on Amazon Prime we are able to reduce costs and at the same time help eliminate unwanted shipping costs to the consumer.”

 

Medical Product Sales On The Rise At Recreational Cannabis Shops

By Sue Vorenberg
Cannabis Daily Record

WASHINGTON: Recreational cannabis shops in Southwest Washington are seeing an increasing demand for products with medical properties, such as high CBD edibles and cannabis-infused topicals for pain.

Store managers and owners at the Cannabis Country Store in Battle Ground and The Herbery in Vancouver, Washington, report so much demand for CBD-based products that at times they say it’s hard to keep up.

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“CBDs are on the rise – we really can’t carry enough of it,” said Jim Mullen, chief operating officer at The Herbery, which has two stores in Vancouver. “We have so many people coming in looking for it.”

CBD, or cannabidiol, is a non-psychoactive component of cannabis used in medical marijuana markets for pain relief, as an anti-inflammatory and for reducing seizures. Requests for high CBD products – or products with a balance of CBD and THC, the psychoactive component of cannabis – at recreational stores often come from customers looking for relief of nausea, pain and a variety of other issues.

Initially there weren’t many high-CBD products in Washington’s recreational market because owners and growers anticipated the greatest demand would be for high-THC cannabis. But as more Baby Boomers and older Americans return to marijuana in legal markets, the demand is changing.

Curt’s Cannabis Corner: What is Nanoemulsion Technology? Part 2

Welcome to the third installment in the series of educational articles from technical writer Curt Robbins at Higher Learning LV and MJBA’s MJNews Network. This collection is intended for cannabis and hemp industry professionals who wish to gain a better understanding of the nuanced biochemistry of this specialand newly legalherb. 

For the past two weeks, Curt has been teaching readers about the hot new manufacturing process for cannabis- and hemp-infused products called nanoemulsion

What is nanoemulsion? How can it help patients and consumers while offering additional marketing opportunities for entrepreneurs? How does it compare to traditional formulation technologies? Read on to learn!


CURT’S

CANNABIS

CORNER 

What is Nanoemulsion Technology?

Part 2

By Curt Robbins

 

 

Read What is Nanoemulsion Technology?: Part 1. In Part 1, readers learn the definition of nanoemulsion and how it is being employed in the cannabis and hemp industries for the creation of consumer products that feature enhanced bioavailability (including greater potency and faster onset). This formulation tech also allows more accurate dosing, a large advantage to millions of patients and their caretakers. 

In Part 2, let’s dive deeper into this excerpt from the Higher Learning LV course Cannabis Core Concepts by further exploring bioavailability issues, examining some real world metrics, and learning the latest scientific research about nanoemulsion technology! 

End Game: Increased Bioavailability

The purpose of packaging a medicine, wellness tonic, or lifestyle beverage in the form of a nanoemulsion is straightforward: To improve bioavailability. This includes not only greater potency, but also faster onset. 

Onset is an important issue for consumers who require quick relief from conditions such as chronic pain, nausea, seizure activity, and social anxiety, to name only a few. Most within this population cannot tolerate the approximately two-hour wait that characterizes the onset of standard infused edible products (especially given that peak potency requires an additional one to three hours). 

The exact onset period of a particular nanoemulsion depends on several factors, including consumption avenue and the biophysical circumstances under which it is consumed by users. This includes their age, relative health, genetic makeup, medical history, and use of commingling drugs.  

Edible cannabis products formulated with nanoemulsions typically involve an onset period of roughly 10-30 minutes, with 15-20 minutes being a common claim among companies offering infused beverages and edibles featuring nanoencapsulated cannabinoids and terpenes.   

A 2014 study entitled “Enhancement of the Oral Bioavailability of Breviscapine by Nanoemulsion Drug Delivery System” that was published in the journal Drug Development and Industrial Pharmacy explored the ability of a “nanoscale drug delivery system to realize the improvement of its oral bioavailability.” 

Reported the study, “the relative bioavailability of [the nanoencapsulated drug] reached 250 percent.” The researchers concluded that the nanoemulsion enhanced the oral absorption of [the drug] due to “improved stability and permeation.”  

A 2017 study entitled “Nanoemulsion-based Delivery System for Enhanced Oral Bioavailability” that was published in the journal Drug Delivery investigated the relative bioavailability of various formulation approaches, including nanoemulsion. “Nanoemulsion of BBH showed a relative bioavailability of 440 percent compared with unencapsulated BBH.” The study’s authors also reported that the nanoencapsulated liquid remained stable following a six-month evaluation period.  

If performed properly and depending on the exact compounds involved, nanotechnology can result in faster onset and greater potency at lowerand significantly more accuratedoses. This approach offers not only more efficient treatment of conditions such as pain and seizures, but also the economy resulting from smaller volumes of a particular compound or drug that yield greater potency.

Detailed Definitions

Research has revealed that bioavailability of cannabinoids such as CBD and CBG may be increased from as low as six percent in traditional, non-nanoemusified preparations (revealed by this study) to as great as 90 percent with nanoemulsified products (demonstrated by another study). 

According to a 2010 study entitled “Nanoemulsion: A Pharmaceutical Review,” nanoemulsion-based products are “by far the most advanced nanoparticle systems for the systemic delivery of biologically active agents for controlled drug delivery and targeting.” The study noted that nanoemulsion droplet sizes within a particular sample, when accomplished successfully, feature “narrow size distributions” (variance).  

“Nanoemulsions are the thermodynamically stable isotropic system in which two immiscible liquids (water and oil) are mixed to form a single phase by means of an appropriate surfactant [or emulsifying agent] or its mix with a droplet diameter in the range of 0.5-100 nm,” reported the study’s authors. The research concluded that “nanoemulsion shows great promise for the future of cosmetics, diagnostics, drug therapies, and biotechnologies.”

According to a 2014 study published in the journal 3 Biotech, a nanoemulsion is a “fine oil/water or water/oil dispersion” featuring a droplet size range of 20–600 nm. The study explained that three primary types of nanoemulsions exist: “(a) oil in water nanoemulsion in which oil is dispersed in water, (b) water in oil nanoemulsions in which water droplets are dispersed in oil, and (c) bi-continuous nanoemulsions.”

Nanoemulsion Research Studies

Although a relatively new technology, serious peer-reviewed research reports have begun to emerge regarding nanoemulsions. These study results consistently demonstrate significantly greater bioavailability, including shorter onset periods and enhanced peak potency. Nanoemulsion tech has shown this effect for a variety of cannabis-derived compounds, including CBD.

A 2016 study entitled “Nanoemulsions: Formation, Properties, and Applications” that was published in the journal Soft Matter noted a number of advantages to the use of nanoemulsion technology for delivery of drugs, including a small size that “leads to useful properties such as high surface area per unit volume, robust stability, [and] optically transparent appearance.” 

The research also noted the different forms of drug delivery in which nanoemulsion technology can improve bioavailability, which include “topical, ocular, intravenous, internasal, and oral delivery.” 

The study reported that most nanoemulsions are transparent in appearance because the droplet size employed “is significantly smaller than the wavelength of visible light.” However, the researchers noted that product and drug formulators “can easily tune the appearance of nanoemulsions to range from transparent to milky white” through the adjustment of droplet size. 

A 2017 study entitled “Biocompatible Nanoemulsions Based on Hemp Oil and Less Surfactants for Oral Delivery of Baicalein with Enhanced Bioavailability” that was published in the International Journal of Nanomedicine aimed to “probe the potential of nanoemulsions consisting of hemp oil in ameliorating [improving] the oral bioavailability of [the flavonoid] baicalein.” 

The study involved a particle size of 90 nm and an impressive bioavailability (what the study called an “entrapment efficiency”) of 99.31 percent. It reported that the flavonoid’s oral bioavailability was increased by “up to 524.7 percent and 242.1 percent relative to the suspensions and conventional emulsions, respectively.” 

The research determined that the safety profile of the flavonoid-based nanoemulsion revealed safe oral consumption. “Our findings suggest that such a novel…preparative process provides a promising alternative to current formulation technologies” and that nanoencapsulation is suitable for “oral delivery of drugs that feature…bioavailability issues.”

A 2017 study entitled “Nanoemulsion: A Novel Eon in Cancer Chemotherapy” that was published in the journal Mini Reviews in Medicinal Chemistry investigated the role of nanoemulsions in the effective treatment of cancer. 

The study’s authors observed that nanoemulsions offer a new approach to improving the sometimes poor bioavailability issues that have plagued traditional preparations and formulations for generations. Reported the study, “the research fraternity has acknowledged nanoemulsions as…capable of effectively addressing the low bioavailability…issues associated with conventional anticancerous chemotherapeutic dosage forms.”

A 2019 study entitled “Development of a Novel Nano­emulsion Formulation to Improve Intestinal Absorption of Cannabidiol” that was published in the journal Medical Cannabis and Cannabinoids observed the relatively poor bioavailability of CBD when ingested orally. “Cannabidiol (CBD) is highly lipophilic [fat loving] and its oral bioavailability is known to be very low in humans.” 

The study developed a novel nanoemulsion preparation of CBD involving a droplet size of approximately 35 nm “to improve the poor solubility and absorption of CBD.” The research reported that significant improvements in bioavailability were afforded by the nanoemulsification process. The period to achieve peak bioavailability (delay from time of consumption) was shortened by 330 percent and its potency was increased by 65 percent compared to a traditional non-nanoemulsified CBD oil. 

The study’s authors observed that their research was “the first to develop a CBD-based nanoemulsion formulation for testing,” which they observed to “extensively enhance the absorption of CBD and improve its bioavailability.”

A 2019 study entitled “Quercetin Loaded Nanoemulsion-based Gel for Rheumatoid Arthritis” that was published in the journal Biomedicine & Pharmacotherapy explored the advantages of a nanoemulsified topical application for the treatment of arthritis. 

The study found the nanoemulsified gel to feature improved bioavailability and “confirmed adequate rheological behavior with a good texture profile and improved drug permeation.” The report’s authors concluded that the nanoemulsified gel featuring the flavonoid quercetin “is an efficient topical treatment strategy for rheumatoid arthritis.” 

A 2019 study entitled “Emulsiogenesis and the Emergence of Nanoemulsions” that was published in the journal Matter investigated “the origin of the first natural emulsions and the evolution in production, classification, and nomenclature of extremely fine colloidal emulsions.”

The study reported that the first emulsions in nature appeared without the help of homo sapiens (and long before their appearance on the planet), about three to four billion years ago. It detailed how the emergence of waterborne microbes “produced organic hydrocarbon molecules, which were large enough in molar mass that collections of [them] formed liquid oil droplets surrounded by water.”

The researchers explained how the history of human-crafted emulsions dates back more than one hundred years. “Small-scale emulsions have been the subject of serious scientific investigations for more than a century, leading to very important milestones in condensed matter.”

The study emphasized how nanoemulsion tech remains in its infancy and that future developments will lead to novel and commercially enticing methods of encapsulating particular types of molecules for storage, distribution, and consumptionall while maintaining maximum bioavailability. 

“Regardless of the trends in nomenclature used for classifying emulsions, it is clear that emulsions having the smallest attainable droplet sizes, increasingly complex chemical compositions, and even multiple internal compartments represent a fertile area for basic research and important applications over many decades to come,” concluded the study’s authors. 

It’s a Wrap

Nanoemulsion technology offers patients and lifestyle consumersand the companies that serve thema way to encapsulate wellness molecules such as CBD, CBG, and THC that features improved stability and greater bioavailability than more traditional formulation techniques, including standard oils and liposomes. 

Heavily regulated industries such as hemp and cannabis benefit significantly from products that are formulated in a manner that leads to maximum shelf life and that can ensure sometimes lengthy storage periods. Greater bioavailability, in turn, offers both lifestyle consumers and multiple patient populations the advantage of rapid onset and enhanced potency. Medical professionals and caretakers are demonstrating an affinity for nanoemulsions based on not only enhanced bioavailability, but also more accurate dosing.   

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Cresco Labs Launches Hemp CBD Subsidiary — Expands House Of Brands

ILLINOIS: Cresco Labs, one of the largest vertically integrated multi-state cannabis operators in the nation, today announced the formation of a new wellness subsidiary, Well Beings, that will provide the Company the ability to expand its house of branded products to all 50 states to potentially reach a new customer base outside of the licensed dispensary channel. Well Beings, led by Cresco’s Chief Experience Officer, MINIMAL principal, and former Nike Global Creative Director Scott Wilson, will offer a full line of high-quality hemp-based CBD wellness products eligible for national distribution. The subsidiary will have its own unique product line and produce CBD versions of Cresco Labs’ house of branded products including Cresco, Remedi and Mindy’s Edibles.

“Entering the CBD industry is an obvious next step for Cresco Labs so it can continue to build consumer trust in the quality and consistency of our portfolio of brands across all fifty states and to reach new customers both through and outside of the licensed dispensary channel,” said Cresco’s CEO and co-founder Charlie Bachtell. “As the US cannabis market is projected to expand from $10 billion to $75 billion by 2030, hemp-derived products, including CBD, offer all consumers an opportunity to access the natural therapeutic benefits of cannabinoid-based products. Our wellness-focused offerings, which will include Well Beings, Cresco, Remedi and Mindy’s, can be distributed nationwide for retailers, grocers, nutrition stores, and online marketplaces, further raising the awareness of cannabinoid-based products and their beneficial properties.”

“We believe that the role of national brands is to help consumers and patients make choices that are right for them. Cresco’s mission is to normalize and professionalize the cannabis industry. By building brands that help de-stigmatize, educate and build trust, we can help new and existing consumers explore the many benefits of cannabis and cannabinoid-based products.”

Following the recent passing of the 2018 Farm Bill legalizing CBD, the hemp CBD market is estimated to reach $3 billion by 2020, according to Brightfield Group, and may possibly eclipse the cannabis market over time. Well Beings builds on Cresco’s strong history of product quality and consistency to offer consumers trustworthy, high quality CBD-based wellness products that will be available in ingestibles, topicals and patches, balms, lotions and tinctures.

Combining the cannabinoid products expertise of Cresco Labs with the design and consumer expertise from Wilson’s MINIMAL, a globally recognized design firm, this new subsidiary will create a launching pad for new brands and support expansion of Cresco’s leading cannabis brands into the CBD space. Well Beings will serve an important new customer category that can experience hemp-based products in a normalized and de-stigmatized manner. Cresco Labs will be making a non-material investment in this new subsidiary.

“The purpose of this new business line is to demystify and build trust in CBD products, guiding consumers to understand the benefits of hemp and how to incorporate CBD-based wellness products into their daily lives,” said Wilson, who is spearheading the endeavor. “The cross-channel, consumer-centric opportunity for Cresco to build brand equity is transformative in the cannabis industry.”

Librede Receives Patent For Cannabidiolic Acid (CBDA) Production In Yeast

CALIFORNIA: Librede, a leader in natural cannabinoid biosynthesis, has been granted a new patent for the production of cannabidiolic acid (CBDA) in microorganisms.

The patent, Production of Cannabidiolic Acid in Yeast, describes the modification of yeast to produce CBDA from simple feedstocks such as sugar. CBDA is a naturally occurring cannabinoid found in hemp and cannabis which is used to produce cannabidiol (CBD). Cannabidiol has been shown to have a wide range of therapeutic properties, including treatment of epilepsy, for which a CBD-based therapeutic has won recent FDA approval.

 Librede is now in the process of continuing technology development through optimization and scaling for industrial production in large fermenters. Dr. Anthony Farina, Librede’s Chief Scientific Officer, explains: “We have been building our platform around the natural biochemistry in the cannabis plant that gives rise to a diverse set of compounds, with our focus being on therapeutic applications. Having engineered cannabidiol synthesis in the laboratory, we are now beginning the process of scaled up production.”

Fermentation for the production of high value, complex, natural products offers a preferred route to synthesis at an industrial scale. Librede’s biosynthetic approach has several potential advantages over agricultural-based methods including protection from supply volatility, improved consistency, reduced cost, and lower environmental impact. Dr. Jason Poulos, CEO of Librede, explains: “The use of fermentation to produce these compounds represents the future of industrial scale cannabinoid production. As more cannabinoids are shown to have therapeutic value, we must find a way to produce these compounds in a sustainable way. Utilizing the synthetic power of biology allows us economical access to these compounds while minimizing environmental impacts. The future of all cannabinoid production may not be large farm fields but instead compact and highly efficient fermenters.”

The Growth Of The Hemp CBD Markets

NEW YORK: According to a research conducted by Hemp Business Journal and Vote Hemp, the Hemp CBD is a market with $130 million in sales with growth at a 53% AGR (Adjusted Growth Revenue). This as a result contributed to the $688 million in total Hemp sales in 2016.

The Hemp CBD category was led by channel sales in natural and specialty products such as smoke shops and online verticals. As well in 2016, SPINS, the leading market research firm for natural products, has listed that $2,470,000 worth of products has used CBD as a primary ingredient. Currently CBD-based pet care products are a ‘growth category to watch’ in 2017.

Eric Steenstra, President of Vote Hemp has referenced, “To date, 31 states have passed legislation that allows hemp farming per provisions set forth in the 2014 Farm Bill, and the U.S. remains the largest consumer market for hemp products worldwide. We need Congress to pass federal legislation to allow commercial hemp farming nationally, to let our farmers and American businesses take advantage of the robust economic opportunity hemp provides.”